Xolnic

Xolnic Dosage/Direction for Use

zoledronic acid

Manufacturer:

Khandelwal Lab

Distributor:

Ni Lay Naing
Full Prescribing Info
Dosage/Direction for Use
Hypercalcaemia of Malignancy: The recommended dose of Zoledronic acid in hypercalcaemia (albumin corrected serum calcium = 12 mg/dl) is 4 mg. The 4 mg is given as a single dose i.v. infusion over 15 minutes. Patients should be adequately rehydrated prior to administration of Zoledronic acid. Retreatment with Zoledronic acid is 4 mg, may be considered if serum calcium does not return to normal or remain normal after initial treatment. It is recommended that a minimum of 7 days elapse before retreatment, to allow for full response to the initial dose.
Multiple Myeloma and metastatic bone Lesions of solid Tumors: The recommended dose of Zoledronic acid in patients with multiple myeloma and metastatic bone lesions from solid tumors for patients with creatinine clearance greater than 60mL/min is 4 mg infused over no less than 15 min every 3-4 weeks.
The recommended doses of Zoledronic acid for patients with reduced renal function are listed in following table: See Table 2.

Click on icon to see table/diagram/image

Co-administrater oral calcium supplements of 500 mg and a multiple vitamin containing 400 IU of Vitamin D daily.
Preparation of solution: Xolnic lyophilized powder for infusion is reconstituted by adding 5 ml of sterile water for injection to each vial. The resulting concentration allows for withdrawal. The content of the reconstituted vials are withdrawn and further diluted in 100 ml of sterile 0.9% sodium chloride or 5% Dextrose injection. Do not store undiluted concentrate in a syringe, to avoid inadvertent injection. The dose must be given as a single intravenous solution infusion over no less than 15 minutes.
If not used immediately after dilution with infusion media, for microbiological integrity, the solution should be refrigerated at 2ºC-8ºC (36ºF-46ºF).
Zoledronic acid must not be mixed with calcium-containing infusion solution, such as Lactated Ringer's solution, and should be administered as a single intravenous solution in a line separate from all other drugs.
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