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Oxaliplatin induces irinotecan-related cholinergic syndrome by potentiating irinotecan inhibition of acetylcholinesterase. Oxaliplatin has no influence on fluorouracil and topotecan pharmacokinetics. Preclinical studies have shown oxaliplatin to be synergistic with fluorouracil and SN-38, the active metabolite of irinotecan.
There are no other studies documenting any major interactions of oxaliplatin with other drugs.
