Xalipat-50/Xalipat-100 Dosage/Direction for Use

As single agent: When used alone, the recommended dose of Oxaliplatin is 130 mg/m² as a continuous intravenous infusion over 2 to 6 hours. The dose may be repeated at an interval of 3 weeks.
In combination therapy: IV: On day 1, administer oxaliplatin 85mg/m² concurrently with leucovorin 200 mg/m² (in separate containers using a Y line) by IV infusion over 2 hours. Then administer fluorouracil 400 mg/m² by IV injection over 2 to 4 minutes, followed by fluorouracil 600 mg/m² by IV infusion over 22 hours.
On day 2, administer leucovorin 200mg/m² by IV infusion over 2 hours. Then administer fluorouracil 400 mg/m² by IV injection over 2 to 4 minutes, followed by fluorouracil 600 mg/m² by IV infusion over 22 hours. Repeat regimen at intervals of 2 weeks. (See Table 2.)

Click on icon to see table/diagram/image

Do not administer next dose until neutrophil count is > 1500 / mm³ and platelet count > 75.000 /mm³.
Renal Impairment: In patients with impaired renal function, observe caution.
Monitoring Parameters: Asses the patient for differential WBC count, hemoglobin, platelet count and ALT, AST, bilirubin and creatinine levels before each Xalipat cycle.