If Biotin is used with anticonvulsants the concentration of Biotin in plasma can be decreased due to the increase of Biotin’s excretion with urine. Valproic acid reduces activity of biotinidase by diminishing the mitochondrial function of liver.
The albumen of raw egg contains protein avidin, which is antagonist to biotin, therefore it is necessary to avoid their simultaneous use. The use of plenty of raw eggs for 2 - 3 weeks can cause biotin deficiency. The Pantothenic acid being used in large doses competes with biotin therefore it is necessary to avoid their simultaneous use