Velcade Caution For Usage

Instructions for Use, Handling and Disposal: Administration Precautions: VELCADE is an antineoplastic. Caution should be used during handling and preparation. Proper aseptic technique should be used. Use of gloves and other protective clothing to prevent skin contact is recommended. In clinical trials, local skin irritation was reported in 5% of patients, but extravasation of VELCADE was not associated with tissue damage.
When administered subcutaneously, alternate sites for each injection (thigh or abdomen). New injections should be given at least one inch from an old site and never into areas where the site is tender, bruised, red, or hard.
There have been fatal cases of inadvertent intrathecal administration of VELCADE. VELCADE is for IV and subcutaneous use only. DO NOT ADMINISTER VELCADE INTRATHECALLY.
Reconstitution/Preparation for Intravenous Administration: The contents of each vial should be reconstituted only with normal (0.9%) saline according to the following instructions based on route of administration: see Table 29.

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The reconstituted product should be a clear and colorless solution.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. If any discoloration or particulate matter is observed, the reconstituted product should not be used.
Procedure for Proper Disposal: Any unused product or waste material should be disposed of in accordance with local requirements.
Incompatibilities: This product must not be mixed with other medicinal products except those mentioned in Instructions for Use, Handling and Disposal.