Complicated skin and soft tissue infections
Adult: 15-20 mg/kg 8-12 hourly via slow infusion of at least 60 minutes or at Max rate of 10 mg/min (whichever is longer). Max: 2,000 mg/dose. Seriously ill patients: Initially, 25-30 mg/kg to facilitate rapid attainment of the target trough serum vancomycin concentration. Adjust dose according to plasma concentration monitoring. Treatment duration: 7-14 days (non-necrotising); 4-6 weeks (necrotising). Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: Term and pre-term neonates' dosage are based on post-menstrual age in weeks, refer to detailed product guidelines. 1 month to <12 years 10-15 mg/kg 6 hourly via slow infusion of at least 60 minutes or at Max rate of 10 mg/min (whichever is longer). ≥12 years Same as adult dose. Treatment duration: 7-14 days (non-necrotising); 4-6 weeks (necrotising). Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: Term and pre-term neonates' dosage are based on post-menstrual age in weeks, refer to detailed product guidelines. 1 month to <12 years 10-15 mg/kg 6 hourly via slow infusion of at least 60 minutes or at Max rate of 10 mg/min (whichever is longer). ≥12 years Same as adult dose. Treatment duration: 7-14 days (non-necrotising); 4-6 weeks (necrotising). Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Intravenous
Bone and joint infections, Infective endocarditis
Adult: 15-20 mg/kg 8-12 hourly for 4-6 weeks via slow infusion of at least 60 minutes or at Max rate of 10 mg/min (whichever is longer). Max: 2,000 mg/dose. Seriously ill patients: Initially, 25-30 mg/kg to facilitate rapid attainment of the target trough serum vancomycin concentration. Adjust dose according to plasma concentration monitoring. Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: Term and pre-term neonates' dosage are based on post-menstrual age in weeks, refer to detailed product guidelines. 1 month to <12 years 10-15 mg/kg 6 hourly for 4-6 weeks via slow infusion of at least 60 minutes or at Max rate of 10 mg/min (whichever is longer). ≥12 years Same as adult dose. Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: Term and pre-term neonates' dosage are based on post-menstrual age in weeks, refer to detailed product guidelines. 1 month to <12 years 10-15 mg/kg 6 hourly for 4-6 weeks via slow infusion of at least 60 minutes or at Max rate of 10 mg/min (whichever is longer). ≥12 years Same as adult dose. Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Intravenous
Community-acquired pneumonia, Hospital-acquired pneumonia, Ventilator associated pneumonia
Adult: 15-20 mg/kg 8-12 hourly for 7-14 days via slow infusion of at least 60 minutes or at Max rate of 10 mg/min (whichever is longer). Seriously ill patients: Initially, 25-30 mg/kg to facilitate rapid achievement of the target trough serum concentration. Adjust dose according to plasma concentration monitoring. Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: Term and pre-term neonates' dosage are based on post-menstrual age in weeks, refer to detailed product guidelines. 1 month to <12 years 10-15 mg/kg 6 hourly for 7-14 days via slow infusion of at least 60 minutes or at Max rate of 10 mg/min (whichever is longer). ≥12 years Same as adult dose. Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: Term and pre-term neonates' dosage are based on post-menstrual age in weeks, refer to detailed product guidelines. 1 month to <12 years 10-15 mg/kg 6 hourly for 7-14 days via slow infusion of at least 60 minutes or at Max rate of 10 mg/min (whichever is longer). ≥12 years Same as adult dose. Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Intravenous
Prophylaxis of endocarditis
Adult: In patients at high risk of developing bacterial endocarditis when undergoing major surgery: Initially, 15 mg/kg prior to induction of anaesthesia; may repeat dosage depending on the duration of surgery.
Oral
Staphylococcal enterocolitis
Adult: 500-2,000 mg in 3-4 divided doses for 7-10 days. Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: 40 mg/kg in 3-4 divided doses for 7-10 days. Max: 2,000 mg daily. Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: 40 mg/kg in 3-4 divided doses for 7-10 days. Max: 2,000 mg daily. Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Oral
Clostridioides difficile infection
Adult: 125 mg 6 hourly for 10 days for the 1st episode of non-severe infection; may increase to 500 mg 6 hourly for 10 days for severe or complicated infection. Max: 2,000 mg daily. For multiple recurrences: 125 mg 4 times daily for 10 days followed by either dose tapering (gradually decreasing dose until 125 mg daily) or pulse treatment (125-500 mg every 2-3 days for at least 3 weeks). Dosage recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: <12 years As oral solution: 10 mg/kg 6 hourly for 10 days. Max: 2,000 mg daily. ≥12 years Same as adult dose. Dosage recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: <12 years As oral solution: 10 mg/kg 6 hourly for 10 days. Max: 2,000 mg daily. ≥12 years Same as adult dose. Dosage recommendations may vary among countries and individual products (refer to specific product guidelines).