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Hypersensitivity to agomelatine or to any of the excipients of Valdoxan.
Patients with hepatic impairment (ie, cirrhosis or active liver disease) or transaminases exceeding 3 x ULN (see Precautions).
Concomitant use of potent CYP1A2 inhibitors (eg, fluvoxamine, ciprofloxacin).
