Unoprostone: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Ophthalmic
Glaucoma, Ocular hypertension

Adult: Instil 1 drop of 0.12% or 0.15% solution into affected eye(s) bid.

Contraindications

Pregnancy; lactation.

Special Precautions

Monitor for eye colour change; risk factors for cystoid macular oedema. An interval of at least 5 min to be observed between different eyedrops. Contact lens to be re-inserted at least 15 min after application of unoprostone.

Adverse Reactions

Conjunctival hyperaemia, brown pigmentation particularly in those with mixed-color irides; ocular irritation and pain; darkening, thickening and lengthening of eyelashes; keratitis; corneal erosion and pain; discharge; burning; ocular itching; punctate epithelial keratopathy; headache; nasal congestion; dry mouth; tongue tip numbness; nausea; vomiting; palpitation; cystoid macular oedema; uveitis.

Pregnancy Category (US FDA)

Ophth: C

Action

Description: Unoprostone, a synthetic analogue of dinoprost (prostaglandin F_2α), decreases intraocular pressure by increasing the uveoscleral outflow of aqueous humour.

Storage

Store below 8°C.

MIMS Class

Antiglaucoma Preparations

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