Tripelennamine: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Hypersensitivity reactions

Adult: As hydrochloride: 25-50 mg every 4-6 hr. Max: 600mg daily.
Child: As hydrochloride: 5 mg/kg in 4-6 divided doses daily. Max: 300mg daily.

Contraindications

Neonates.

Special Precautions

Narrow-angle glaucoma, urinary retention, prostatic hypertrophy, pyloroduodenal obstruction, epilepsy. Avoid operating vehicles or machinery. Elderly.

Adverse Reactions

Sedation; CNS depression; antimuscarinic effects; GI disturbances.
Potentially Fatal: Blood dycrasias.

Drug Interactions

Increased sedation with CNS depressants eg, alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytics, sedatives and antipsychotics. Increased antimuscarinic side effects with other antimuscarinic drugs e.g. atropine, TCAs and MAOIs. May mask signs of ototoxicity caused by aminoglycosides.

Lab Interference

May suppress histamine response to allergens and thus may interfere with skin testing.

Action

Description: Tripelennamine is an antihistamine derived from ethylenediamine with antimuscarinic and moderate sedative properties.

MIMS Class

Antihistamines & Antiallergics

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