Generic Medicine Info
Indications and Dosage
Prophylaxis of thromboembolic disorder
Adult: Usual dose: 300-900 mg daily.
Should be taken with food.
Adverse Reactions
Nausea, vomiting, gastric and epigastric pain, erythema, conjunctival haemorrhage, epistaxis.
Description: Triflusal, a derivative of salicylic acid, is an inhibitor of platelet aggregation. It inhibits platelet arachidonic metabolism and stimulates platelet cAMP production. Unlike aspirin, it does not increase bleeding time. It may also have neuroprotective effects as animal studies have shown that it blocks the biochemical pathway that leads to cell damage during ischemia in the nervous system.
Absorption: Bioavailability: 83-100%. Peak plasma concentration: 0.88 hr (triflusal); 4.96 hr (HTB).
Distribution: Protein binding: extensive.
Metabolism: Rapidly metabolised by liver to active metabolite, 3-Hydroxy-4-trifluoro-methylbenzoic acid (HTB).
Excretion: Via urine as metabolites. Terminal half life: 0.53 hr (triflusal); 34.29 hr (HTB)
MIMS Class
Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)
Disclaimer: This information is independently developed by MIMS based on Triflusal from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
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