Trifluridine: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Ophthalmic
Primary herpes simplex keratoconjunctivitis, Recurrent herpes simplex virus epithelial keratitis

Adult: As 1% soln: Instill 1 drop into affected eye 2 hrly. Max: 9 drops daily, until complete re-epithelialisation. Reduce to 1 drop 4 hrly (Min 5 drops daily) for 7 days. Treatment should not exceed 21 days.
Child: ≥6 yr Same as adult dose.

Contraindications

Hypersensitivity.

Special Precautions

Childn. Pregnancy and lactation.

Adverse Reactions

Mild conjunctival or corneal irritation/burning/stinging, palpebral and stromal oedema, superficial punctate and epithelial keratopathy, hyperaemia, increased intraocular pressure.

Pregnancy Category (US FDA)

Ophth: C

Action

Description: Trifluridine is a fluorinated pyrimidine nucleoside that is active against HSV, vaccinia virus, CMV, and some adenovirus. It interferes w/ viral replication by inhibiting thymidylate synthetase and incorporating into viral DNA in place of thymidine.
Onset: W/in 2-7 days.
Pharmacokinetics:
Absorption: Absorbed through the cornea w/ increased penetration in the presence of epithelial defect or w/ stromal/uveal inflammation.
Excretion: Elimination half-life: 12 min.

Chemical Structure

Storage

Store between 2-8˚C.

MIMS Class

Eye Anti-Infectives & Antiseptics

ATC Classification

S01AD02 - trifluridine ; Belongs to the class of antiinfectives, antivirals. Used in the treatment of eye infections.

References

Anon. Trifluridine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/07/2016.

Buckingham R (ed). Trifluridine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/07/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Trifluridine (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 08/07/2016.

Trifluridine Solution (Falcon Pharmaceuticals, Ltd.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 08/07/2016.

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