Depression
Adult: 200 mg tid.
Indications and Dosage
Oral
Depression Adult: 200 mg tid.
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Contraindications
Pregnancy, lactation.
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Special Precautions
Stop toloxatone 6 hr before general anaesthesia. Monitor BP at the start of treatment.
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Adverse Reactions
Dysuria, nausea, constipation, vertigo, insomnia.
Potentially Fatal: Fulminant hepatitis. |
Drug Interactions
Increased risk of serotonin syndrome with SSRI, TCA. Increased BP with sympathomimetics. Increased concentration of triptans.
Potentially Fatal: Increased risk of hypertension and CNS excitation when given with MAOI, wait for 15-20 days after end of MAOI therapy before starting toloxatone. |
Food Interaction
Increased BP with large amounts of tyramine-rich food.
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Action
Description: Toloxatone is a reversible inhibitor of monoamine oxidase type-A (RIMA).
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MIMS Class
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