Tocopheryl nicotinate

Generic Medicine Info
Indications and Dosage
Adult: 100-200 mg tid, adjust dose based on patient's age and symptoms.

Symptoms associated with hypertension, Symptoms associated with cerebral arteriosclerosis and sequelae of cerebral apoplexy, Peripheral circulatory disturbance resulting from arteriosclerosis obliterans
Adult: 100-200 mg tid, adjust dose based on patient's age and symptoms.
Adverse Reactions
Nausea, diarrhoea, constipation, stomach ache/discomfort, anorexia, rash, flushing, oedema, and liver dysfunction (elevated AST, ALT).
Food Interaction
Higher absorption when administered after a meal.
Description: Tocopheryl nicotinate is the esterified compound of tocopherol and nicotinic acid which has more potent pharmacological activity than a dose of both drugs given concurrently. Tocopheryl nicotinate is a lipid regulating drug which can reduce total serum cholesterol and triglycerides, and increase HDL cholesterol. It has also been shown to enhance microcirculation, inhibit platelet aggregation, prevent capillary fragility, and restore arterial oxygen partial pressure.
Absorption: Following a single oral admin of 600 mg dose, Tmax of Tocopheryl nicotinate (unchanged form): About 6 hr; tocopherol (hydrolysed form): About 10 hr.
Excretion: Elimination half-life of Tocopheryl nicotinate: About 4.3 hr; tocopherol (hydrolysed form): About 38.5 hr.
Store at room temperature. Protect from heat and moisture.
MIMS Class
Dyslipidaemic Agents / Peripheral Vasodilators & Cerebral Activators
Disclaimer: This information is independently developed by MIMS based on Tocopheryl nicotinate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
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