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Severe renal insufficiency modifies the pharmacokinetics of Diacerein and therefore a dose reduction is recommended in such cases (creatinine clearance < 30 ml/min). When diacerein is taken with food, there is an increase (about 24%) in the absorption of Diacerein; on the other hand, severe nutritional deficiencies decrease the bioavailability of Diacerein. As the incidence of collateral effects, such as accelerated intestinal transit time, is directly proportional to the amount of unabsorbed Diacerein, the intake of the product in a fasting state or after very small amounts of food could cause an increased incidence of collateral effects.
Effect on ability to drive and use machines: No sedative effect, which may affect the ability to handle machines, is known for Diacerein. It should not be prescribed clinical studies have been undertaken in this age-group.
Use in Pregnancy: Safety during Pregnancy is not established hence not recommended in pregnancy.
Use in Lactation: Not recommended in lactating mother as safety in lactating mother is not established.
Use in Children: Safety and effectiveness in children have not been established.
Laxatives should not be taken concomitantly with Diacerein.
