Studies conducted have shown that Diacerein is well tolerated. Commonly seen adverse effects are diarrhoea, and abdominal pain, which are expected owing to the chemical nature of the drug. In small percentage of patient dark yellow coloured urine has been reported. This is due to excretion of diacerein metabolites via the urine and is of no clinical significance. There were no changes in any laboratory safety variables, especially those related to liver and kidney function.