Diacerein must not be administered as the same time as drugs that modify intestinal transit and/or the quality of the intestinal content (eg excess fibres or phytates).
The concomitant administration of products containing aluminium hydroxide and / or magnesium hydroxide should be avoided in order to maximize the bioavailability of Diacerein.
Treatment with Diacerein may cause an increase in enterocolic events in patients undergoing antibiotic and/or chemotherapy which could affect the intestinal flora.