Tirase Dosage/Direction for Use

The usual dosage regimen is one capsule taken orally twice a day with the main meals for prolonged periods (not less than 6 months).
However, as Diacerein may cause acceleration intestinal transit time during the first 2 weeks of treatment, it is recommended that treatment be started with one capsule per day taken orally with evening meal for 4 weeks.
Once the patient has become accustomed to the medication, the dose should be increased to 2 capsules per day, taken orally with meals.
The doctor should decide the duration of treatment as a function of the outcome. However this should not be less than 6 months.
As with prolonged treatment with any other medication, a complete blood test, including liver enzymes, and urine analysis should be conducted every 6 months.
Due to its late onset of action (after 2-4 weeks of treatment). Diacerein may be associated with a non-steroidal anti-inflammatory drug or analgesic for the first 2-4 weeks of treatment.
Children: No Clinical studies have been conducted in children. As the safety and efficacy on the product have not been established in this age group, its use is not recommended.
Elderly: No change in the usual recommended dose is necessary in elderly subjects.
Renal Insufficiency: In subjects with moderate renal insufficiency, the daily dose should be decreased by 50% of the recommended dose for adults.
Diacerein is contraindicated in subjects with severe renal insufficiency.
Hepatic insufficiency: No significant deviations were observed in any of the pharmacokinetic parameters in cirrhotic with mild or moderate hepatic insufficiency and therefore no dose adjustment is required in these patients.
However, the use of diacerein is contraindicated in patients with a severe deterioration of hepatic function.