Thyroid tablets

Generic Medicine Info
Indications and Dosage
Adult: As replacement or supplemental therapy: Initially, 30 mg daily, increase by 15 mg increments every 2-3 weeks according to response. Maintenance dose: 60-120 mg daily.

Congenital hypothyroidism
Child: ≤6 months 4.8-6 mg/kg daily. 6-12 months 3.6-4.8 mg/kg daily. 1-5 years 3-3.6 mg/kg daily. 6-12 years 2.4-3 mg/kg daily. >12 years 1.2-1.8 mg/kg daily.
Special Patient Group
Patient with long-standing myxedema or CV diseases: Initially, 15 mg daily.
Untreated thyrotoxicosis, uncorrected adrenal cortical insufficiency.
Special Precautions
Patient with adrenal insufficiency, angina pectoris and other CV diseases, diabetes mellitus/insipidus, myxedema. Children. Pregnancy and lactation.
Adverse Reactions
Significant: Exacerbation of adrenal insufficiency, diabetes mellitus/insipidus, myxedema, coronary artery disease.
Cardiac disorders: Cardiac arrhythmia, palpitations, tachycardia.
Gastrointestinal disorders: Abdominal cramps, diarrhoea, constipation, vomiting.
General disorders and administration site conditions: Fever.
Investigations: Weight loss.
Metabolism and nutrition disorders: Increased appetite.
Musculoskeletal and connective tissue disorders: Chest pain, myalgia.
Nervous system disorders: Ataxia, headache, heat intolerance, insomnia, nervousness, tremors, tremor of hands.
Reproductive system and breast disorders: Menstrual disease.
Skin and subcutaneous tissue disorders: Alopecia, diaphoresis.
Monitoring Parameters
Monitor TSH, heart rate, blood pressure; signs and symptoms of hypo/hyperthyroidism periodically.
Symptoms: Hypermetabolic state. Management: Symptomatic and supportive treatment. May induce vomiting to suppress gastrointestinal absorption. Administer oxygen and maintain ventilation. May give glycosides if CHF develops; propranolol to treat increased sympathetic activities; cholestyramine to interfere with thyroxine absorption; and glucocorticoids to inhibit conversion of T4 to T3. Control fever, hypoglycaemia and fluid loss as needed.
Drug Interactions
May diminish therapeutic effect of Na iodide. Increased risk of bleeding with vitamin K antagonists (e.g. warfarin). May increase plasma concentration of theophylline; may cause theophylline toxicity. May enhance the arrhythmogenic effect of tricyclic antidepressants. Decreased plasma concentration with bile acid sequestrants (e.g. colestipol, colestyramine) and oral contraceptives (e.g. estrogen). May decrease plasma concentration of digoxin. May cause hypothyroidism when given with amiodarone. May increase need for oral hypoglycemics or insulin.
Potentially Fatal: May cause serious toxic effects with sympathomimetic amines used for anorectic effect (e.g. phentermine).
Food Interaction
Decreased absorption with food, soybean infant formula, cottonseed meal, walnuts and dietary fibre.
Description: Thyroid is a natural product derived from porcine thyroid glands. It provides variable amounts of levothyroxine (T4) and liothyroxine (T3) hormones. The exact mechanism of action has not been fully elucidated, but it is known to enhance oxygen consumption by tissues, increase basal metabolic rate and metabolism of carbohydrate, lipids and proteins.
Synonym: dry thyroid, thyroid extract, thyroid gland, desiccated thyroid.
Onset: Approx 3 hours (T3).
Absorption: Absorbed from the gastrointestinal tract. Decreased absorption with food. Time to peak plasma concentration: 2-4 hours (T4); 2-3 days (T3).
Distribution: Minimal amount crosses the placenta and enters breast milk. Plasma protein binding: >99% (T4) to plasma proteins including thyroxine-binding globulin, thyroxine-binding pre-albumin and albumin.
Metabolism: Undergoes hepatic metabolism via outer ring deiodination by D1 (type 1 iodothyronine deiodinase) and converted to triiodothyronine (T3). Approx 80% T4 deiodinated in kidney and periphery. Glucuronidation and sulfation also occurs; undergoes enterohepatic recirculation.
Excretion: Mainly via urine; partially faeces. Elimination half-life: T4: 9-10 days (hypothyroid); 6-7 days (euthyroid); 3-4 days (hyperthyroid). T3: 0.75 days.
Store between 15-30°C. Protect from light and moisture.
MIMS Class
Thyroid Hormones
ATC Classification
H03AA05 - thyroid gland preparations ; Belongs to the class of thyroid hormones.
Anon. Thyroid, Desiccated. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 09/05/2018.

Anon. Thyroid. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. Accessed 09/05/2018.

Armour Thyroid, Porcine Tablet (Allergan, Inc.). DailyMed. Source: U.S. National Library of Medicine. Accessed 09/05/2018.

Buckingham R (ed). Thyroid. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 09/05/2018.

Nature Thyroid Tablet (PD-Rx Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. Accessed 09/05/2018.

Preston CL (ed). Interactions of Thyroid Hormones. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. Accessed 18/05/2018.

Disclaimer: This information is independently developed by MIMS based on Thyroid tablets from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
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