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Pregnancy: There are limited data on the use of thiocolchicoside in pregnant women. Therefore, the potential hazards for the embryo and foetus are unknown.
Studies in animals have shown teratogenic effects.
Thiocolchicoside cream is contraindicated during pregnancy and in women of childbearing potential not using contraception (see Contraindications).
Breast-feeding: Since it passes into the mother's milk, the use of thiocolchicoside is contraindicated during breastfeeding (see Contraindications).
Fertility: In a fertility study performed in rats, no impairment of fertility was seen at doses up to 12 mg/kg, i.e. at dose levels inducing no clinical effect. Thiocolchicoside and its metabolites exert aneugenic activity at different concentration levels, which is a risk factor for impairment of human fertility.
