Tecavir

Tecavir Mechanism of Action

entecavir

Manufacturer:

Distributor:

KTZ

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Full Prescribing Info

Action

Pharmacology: Entecavir is a guanosine nucleoside analogue with potent and selective activity against HBV polymerase. For pharmacological action, it is phosphorylated to the active triphosphate (TP) form. Entecavir triphosphate functionally inhibits all 3 activities of the viral polymerase; priming of the HBV polymerase, reverse transcription of the negative strand from the pregenomic messenger RNA and synthesis of the positive strand HBV DNA.

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