Generic Medicine Info
Indications and Dosage
Muscle relaxant in general anaesthesia
Adult: As suxamethonium Cl: 3-4 mg/kg. Max: 150 mg.
Child: As suxamethonium Cl: <1 yr Up to 5 mg/kg; ≥1 yr Up to 4 mg/kg. Max: 150 mg.

Muscle relaxant in general anaesthesia
Adult: As suxamethonium Cl: Single dose of 0.3-1.1 mg/kg by inj. Supplementary doses of 50-100% of the initial dose may be given at 5-10 min intervals. For prolonged procedures, 0.1-0.2% soln by infusion at 2.5-4 mg/min, adjusted as necessary. Max (repeated inj or continuous infusion): 500 mg/hr.
Child: As suxamethonium Cl: <1 yr 2 mg/kg; 1-12 yr 1 mg/kg.
IV infusion: Suxamethonium Cl 1 g powd for inj or 20 mL of a soln containing 50 mg/mL may be added to 1,000 mL or 500 mL of diluent (e.g. dextrose 5%, dextrose 5% and NaCl 0.9%, NaCl 0.9%, or (1/6) M Na lactate inj) to provide a soln containing 1 mg/mL (0.1%) or 2 mg/mL (0.2%), respectively. Alternatively, suxamethonium Cl 500 mg powd for inj or 10 mL of a soln containing 50 mg/mL may be added to 500 mL or 250 mL of diluents to provide a soln containing 1 mg/mL (0.1%) or 2 mg/mL (0.2%), respectively.
Alkaline soln w/ pH exceeding 8.5 (e.g. barbiturates). Y-site: Thiopental, heparin.
Genetically determined disorders of plasma pseudocholinesterase; personal or familial history of malignant hyperthermia, myopathies associated w/ elevated serum creatine kinase values, angle-closure glaucoma, penetrating eye injuries, raised intraocular pressure; neurological deficits involving acute major muscle wasting (upper and/or lower motor neuron lesions); extensive denervation of skeletal muscle because of disease or injury to the CNS, pre-existing hyperkalaemia. Patient recovering from major trauma, extensive or severe burns.
Special Precautions
Hypersensitivity to any neuromuscular blocker. Patient w/ reduced plasma cholinesterase activity, bone fractures, neuromuscular disorders, cardiac or resp disease, electrolyte imbalance, suspected cardiac glycoside toxicity. Childn. Pregnancy and lactation.
Adverse Reactions
Prolonged resp depression or apnoea, bradycardia, tachycardia, hypotension, HTN, raised intraocular pressure, hyperkalaemia, muscle fasciculation, excessive salivation, jaw rigidity, rash.
Potentially Fatal: Anaphylactic and anaphylactoid reactions, acute rhabdomyolysis w/ hyperkalaemia followed by ventricular dysrhythmias and cardiac arrest, malignant hyperthermia.
IM/IV/Parenteral: C
Monitoring Parameters
Monitor cardiac function and oxygenation during admin; temp, serum K and Ca, assisted ventilator status; neuromuscular function w/ peripheral nerve stimulator.
Symptoms: Apnoea, prolonged muscle paralysis, decreased resp reserve, low tidal vol. Management: Symptomatic and supportive treatment. Maintain airway and adequate ventilation until recovery of normal respiration is assured. Use of neostigmine to reverse a non-depolarising suxamethonium-induced block should be accompanied by appropriate doses of an anticholinergic agent (e.g. atropine).
Drug Interactions
Prolonged neuromuscular blocking effects w/ specific anticholinesterase agents (e.g. neostigmine), cytotoxic compd (e.g. cyclophosphamide), antiarrhythmics (e.g. quinidine), aminoglycosides, psychiatric drugs (e.g. chlorpromazine), Mg salts, anaesth agents (e.g. morphine), SSRIs, organophosphate insecticides. Increased susceptibility to the effects of suxamethonium-exacerbated hyperkalaemia w/ digitalis-like drugs.
Description: Suxamethonium Cl is an ultrashort-acting depolarising type skeletal muscle relaxant. It blocks the neuromuscular junction by binding to the cholinergic receptors and depolarising it.
Onset: 0.5-1 min (IV); approx 2-3 min (IM).
Duration: 4-6 min (IV); 10-30 min (IM).
Distribution: Crosses the placenta (small amounts).
Metabolism: Rapidly hydrolysed by plasma cholinesterase.
Excretion: Via urine, approx 10% as unchanged drug.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Succinylcholine, CID=5314, (accessed on Jan. 23, 2020)

Store between 2-8°C.
MIMS Class
Neuromuscular Blocking Agents
Anon. Succinylcholine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 29/10/2015.

Buckingham R (ed). Suxamethonium Chloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 29/10/2015.

Joint Formulary Committee. Suxamethonium Chloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. Accessed 29/10/2015.

McEvoy GK, Snow EK, Miller J et al (eds). Succinylcholine Chloride. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). Accessed 29/10/2015.

Quelicin Succinylcholine Chloride Injection, Solution (Hospira, Inc.). DailyMed. Source: U.S. National Library of Medicine. Accessed 29/10/2015.

Disclaimer: This information is independently developed by MIMS based on Suxamethonium from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2023 MIMS. All rights reserved. Powered by
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