Sultopride

Oral
Psychoses

Dose reduction may be needed.

Comatose states, CNS depression, phaeochromocytoma, porphyria, bradycardia. Lactation.

Renal impairment, CV disease, Parkinson's disease, depression. Elderly. May impair ability to drive or operate machinery.

Extrapyramidal effects, parkinsonian symptoms, dystonia, akathesia, tardive dyskinesia, sleep disturbances, overstimulation, agitation, wt gain, sedation, hyperprolactinaemia.
Potentially Fatal: Ventricular arrhythmia e.g. torsade de pointes, neuroleptic malignant syndrome.

Increased risk of ventricular arrhythmia with drugs that prolong QT interval. Increased CNS depression with other CNS depressants e.g. alcohol, general anaesthetics, hypnotics, opioids.

Description: Sultopride has general properties similar to those of sulpiride. It is a dopamine antagonist and is used in the emergency management of agitation in patients who are psychotic or aggressive and in psychoses e.g. schizophrenia. Given as the hydrochloride but doses are expressed in terms of base. Sultopride hydrochloride 441 mg is equivalent to 400 mg sultopride.

Antipsychotics