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Suljac

Suljac

ampicillin + sulbactam

Manufacturer:

Zifam Pinnacle

Distributor:

Pinnacle House
Concise Prescribing Info
Contents
Per 1.5 g vial Ampicillin 1,000 mg, sulbactam 500 mg
Indications/Uses
Infections caused by susceptible microorganisms eg, upper & lower resp tract infections including sinusitis, otitis media & epiglottitis; bacterial pneumonias; UTIs & pyelonephritis; intra-abdominal infections including peritonitis, cholecystitis, endometritis & pelvic cellulitis; bacterial septicemia; skin, soft tissue, bone, joint & gonococcal infections. May also be administered peri-operatively to reduce incidence of post-op wound infections in patients undergoing abdominal or pelvic surgery. Prophylaxis to reduce post-op sepsis.
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Dosage/Direction for Use
IM/IV Adult 1.5-12 g daily in divided doses every 6-8 hr. Max: Sulbactam 4 g daily. Less severe infections may be treated every 12 hr. Mild infection 1.5-3 g daily. Moderate infection Up to 6 g daily. Severe infection Up to 12 g daily. Prophylaxis of surgical infection 1.5-3 g at anesth induction, may be repeated every 6-8 hr. Uncomplicated gonorrhoea 1.5 g as single dose w/ concomitant probenecid 1 g. Childn, infant & neonate 150 mg/kg daily every 6-8 hr. Neonate during 1st wk of life 75 mg/kg daily in divided doses every 12 hr.
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Overdosage
View Suljac overdosage for action to be taken in the event of an overdose.
Contraindications
History of allergic reaction to penicillins.
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Special Precautions
Previous hypersensitivity to penicillins, cephalosporins & other allergens. Discontinue if an allergic reaction; severe skin reactions eg, toxic epidermal necrolysis, Stevens-Johnson syndrome, dermatitis exfoliative, erythema multiforme & acute generalized exanthematous pustulosis; or superinfection w/ nonsusceptible organisms occur. Not to be used in infectious mononucleosis. Periodically check for organ system dysfunction (eg, renal, hepatic & hematopoietic system) during extended therapy. Clostridium difficile-associated diarrhea; drug-induced liver injury eg, cholestatic hepatitis & jaundice. False-positive glycosuria in urinalysis w/ Benedict & Fehling reagent, & Clinitest. Pregnancy & lactation. Neonates (especially premature) & other infants.
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Adverse Reactions
Anaemia, thrombocytopenia, eosinophilia; phlebitis; diarrhea; hyperbilirubinaemia; inj site pain; increased ALT, AST.
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Drug Interactions
Decreased renal tubular secretion w/ probenecid. Ampicillin: Increased incidence of rashes w/ allopurinol. Substantial mutual inactivation w/ aminoglycosides. Altered platelet aggregation & coagulation tests w/ anticoagulants. Bacteriostatic drugs eg, chloramphenicol, erythromycin, sulfonamides & tetracyclines may interfere w/ the bactericidal effect of penicillins. Reduced effectiveness of estrogen-containing OCs. Decreased clearance of methotrexate. May need to increase leucovorin dose & administer for longer periods of time.
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Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view Suljac detailed prescribing information
Storage
View Suljac storage conditions for details to ensure optimal shelf-life.
Description
View Suljac description for details of the chemical structure and excipients (inactive components).
Action
View Suljac mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Penicillins
ATC Classification
J01CR01 - ampicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Presentation/Packing
Form
Suljac powd for inj 1.5 g
Packing/Price
1's
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