Sulconazole: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Tinea corporis, Tinea cruris, Tinea versicolor

Adult: As 1% cream or solution: Apply a small amount and gently massage onto the affected and surrounding area(s) 1-2 times daily. Treatment duration: 3 weeks. Re-evaluate the diagnosis if significant clinical improvement does not occur after 4-6 weeks.

Topical/Cutaneous
Tinea pedis

Adult: As 1% cream: Apply a small amount and gently massage onto the affected and surrounding area(s) bid. Treatment duration: 4 weeks. Re-evaluate the diagnosis if significant clinical improvement does not occur after 4-6 weeks.

Contraindications

Hypersensitivity.

Special Precautions

Patient with hypersensitivity to other imidazole or triazole antifungal agents. The 1% topical solution is not indicated for the treatment of tinea pedis. Pregnancy and lactation.

Adverse Reactions

Significant: Skin irritation or sensitivity.
Skin and subcutaneous tissue disorders: Localised burning and stinging sensation, pruritus, erythema.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Avoid contact with eyes.

Action

Description: Sulconazole is an imidazole derivative synthetic antifungal agent. It inhibits the metabolic reactions necessary for the synthesis of ergosterol, thereby causing changes in membrane permeability and alterations in cell volume, secondary metabolic effects, and defective cell division and growth inhibition.
Pharmacokinetics:
Absorption: Absorbed percutaneously (approx 8.7-11%).
Excretion: Mainly via urine.

Chemical Structure

Storage

Store below 40°C. Protect the topical solution from light.

MIMS Class

Topical Antifungals & Antiparasites

ATC Classification

D01AC09 - sulconazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.

References

Anon. Sulconazole. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 04/08/2022.

Anon. Sulconazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 04/08/2022.

Buckingham R (ed). Sulconazole Nitrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/08/2022.

Exelderm Cream (Journey Medical Corporation). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 04/08/2022.

Sulconazole Nitrate Solution (JG Pharma Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 04/08/2022.

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