Subsyde-CR/Subsyde-M Special Precautions

Subsyde-CR: Accurate diagnosis and careful monitoring are essential in patients with gastrointestinal disorders, a history suggestive of peptic ulcer, ulcerative colitis, or Crohn's disease and in patients with severely impaired hepatic function. Particular caution is called for in patients with impaired cardiac or renal function, as well as in elderly patients. As diclofenac may increase the activity of ≥1 liver enzymes, hepatic function during prolonged treatment should be monitored.
Subsyde-M: Should be applied only to intact skin. It should not come in contact with eyes or mucous membranes.
Use in pregnancy & lactation: In 1st and 2nd trimesters, no controlled studies in pregnant women are available. Subsyde-CR should not be given during the 3rd trimester owing to the risk of premature closure of the ductus arteriosus and suppression of uterine contractility.
As with other drugs that are excreted in milk, diclofenac is not recommended for use in nursing women.
Use in children: Safety and effectiveness of diclofenac in children have not been established.