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Aspirin: Concomitant administration of diclofenac and aspirin is not recommended.
Anticoagulants: Caution should be exercised while administering anticoagulants with diclofenac, since interactions of anticoagulants have been seen with other NSAIDs.
Digoxin, Methotrexate, Cyclosporine and Lithium: Patients who begin taking diclofenac or who increase their diclofenac dose while taking these drugs should be observed closely, particularly if renal function is impaired. In case of digoxin, serum levels should be monitored.
Oral Hypoglycaemics: Isolated cases have been reported of hypoglycaemic and hyperglycaemic reactions necessitating an adjustment in the dosage of antidiabetic drugs during treatment with diclofenac.
Diuretics: Concomitant treatment of diclofenac with potassium-sparing diuretics may raise serum potassium levels, which should therefore be monitored.
