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Subsyde-CR: Diclofenac sodium is sodium -[2-[2,6-dichloroanilino)phenyl]-acetate, which is phenylacetic acid derivatives. Subsyde-CR is a controlled-release formulation which employs the new Diffusion Rate Controlling Membrane Technology (DRCM). Subsyde-CR is a multiple-unit formulation containing many pellets. Each pellet comprises of a core with alternate layers of drug and specially designed membrane, which controls the diffusion rate of the drug contents. After release of pellets into the stomach, entry of water into the pellets takes place by osmosis, starting from the stomach itself. This water dissolves the diclofenac until a saturated solution is formed internally. Diclofenac then diffuses through the dialyzing membrane into the surrounding lumen for absorption into the bloodstream. The dialyzing membrane ensures slow and steady release of the drug for absorption throughout its passage in the intestinal tract. This process continues layer by layer in a slow and steady manner ensuring that plasma diclofenac concentrations are maintained for 24 hrs after a single dose. When the entire drug has diffused out of the pellets, they then collapse and are excreted out.
Subsyde-M: Each tube contains diclofenac diethylamine 1.16% w/w equivalent to diclofenac sodium 1% w/w, linseed oil 3% w/w, methyl salicylate 10% w/w, menthol 5% w/w, methyl hydroxybenzoate 0.1% w/w, propyl hydroxybenzoate 0.025% w/w in a gel base (as needed).
