Tularaemia
Adult: 1-2 g daily in divided doses for 7-14 days until the patient is afebrile for 5-7 days.
Child: 15 mg/kg bid for at least 10-14 days. Max: 2 g daily.
Child: 15 mg/kg bid for at least 10-14 days. Max: 2 g daily.
Intramuscular
Bacterial endocarditis
Adult: Streptococcal endocarditis: 1 g bid for 1 wk, then 500 mg bid for the 2nd wk. Enterococcal endocarditis: 1 g bid for 2 wk then 500 mg bid for an additional 4 wk. Doses are given in combination w/ penicillin.
Child: Enterococcal endocarditis: 20-30 mg/kg daily in 2 divided doses, in combination w/ penicillin.
Elderly: Streptococcal endocarditis: >60 yr 500 mg bid for the entire 2 wk period.
Child: Enterococcal endocarditis: 20-30 mg/kg daily in 2 divided doses, in combination w/ penicillin.
Elderly: Streptococcal endocarditis: >60 yr 500 mg bid for the entire 2 wk period.
Intramuscular
Tuberculosis
Adult: 15 mg/kg as a single dose daily. Max: 1 g daily. As part of intermittent regimen: 25-30 mg/kg 2-3 times wkly. Max: 1.5 g/dose.
Child: 20-40 mg/kg as a single dose daily. Max: 1 g daily. As part of intermittent regimen: 25-30 mg/kg 2-3 times wkly. Max: 1.5 g/dose.
Elderly: >40 yr Max: 500-750 mg daily.
Child: 20-40 mg/kg as a single dose daily. Max: 1 g daily. As part of intermittent regimen: 25-30 mg/kg 2-3 times wkly. Max: 1.5 g/dose.
Elderly: >40 yr Max: 500-750 mg daily.
Intramuscular
Plague
Adult: 2 g daily in 2 divided doses for a minimum of 10 days.
Child: 30 mg/kg daily in 2-3 divided doses. Max: 2 g daily.
Child: 30 mg/kg daily in 2-3 divided doses. Max: 2 g daily.
Intramuscular
Bacteraemia, Brucellosis, Meningitis, Pneumonia, Urinary tract infections
Adult: For concomitant use w/ other agents and as 2nd line agent: 1-2 g daily in divided doses 6-12 hrly. Max: 2 g daily.
Child: 20-40 mg/kg daily in divided doses 6-12 hrly.
Child: 20-40 mg/kg daily in divided doses 6-12 hrly.