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When administered at high doses to pregnant rats (≥40 mg/kg/day) and mice (≥80 mg/kg/day), Sporal was shown to increase the incidence of foetal abnormalities and did produce adverse effects on the embryo. No studies are available on the use of Sporal in pregnant women. Therefore, Sporal should only be given in life-threatening cases of systemic mycosis and when in these cases the potential benefit outweighs the risk.
It is recommended not to breastfeed whilst taking itraconazole.
