Risk of HBV reactivation: Prior to initiation of HCV therapy, test for evidence of current or prior HBV infection, & monitor HCV/HBV coinfected patients for HBV reactivation & hepatitis flare during & post-treatment follow-up. Not recommended for coadministration w/ amiodarone as serious symptomatic bradycardia may occur. Concomitant use w/ P-gp inducers (eg, rifampicin, St. John's wort) may reduce therapeutic effect of Sovir Plus. Pregnancy & lactation. Avoid pregnancy when used in combination w/ ribavirin or peginterferon/ribavirin. Paed <12 yr.