Sodium picosulfate

Generic Medicine Info
Indications and Dosage
Adult: 5-10 mg as a single dose, usually at bedtime.
Child: 1 mth to <4 yr 0.25 mg/kg. Max: 5 mg; 4-10 yr 2.5-5 mg; >10 yr 5-10 mg. Doses are usually given at night.

Bowel evacuation before investigational procedures
Adult: 10 mg, w/ Mg citrate, given in the morning and again in the afternoon of the day before examination.
Child: 1 mth to <4 yr 0.25 mg/kg. Max: 5 mg; 4-10 yr 2.5-5 mg; >10 yr 5-10 mg. Doses are usually given at night.
May be taken with or without food.
Acute inflammatory bowel diseases, severe dehydration, ileus or intestinal obstruction, severe painful and/or feverish acute abdominal conditions (e.g. appendicitis) potentially associated w/ nausea and vomiting.
Special Precautions
Childn. Pregnancy and lactation.
Adverse Reactions
Abdominal discomfort (e.g. abdominal pain and cramps), diarrhoea. Rarely, allergic reactions (e.g. skin reactions, angioedema).
Patient Counseling Information
Should not be taken on a continuous daily basis for long periods. This drug may cause vasovagal response, dizziness and/or syncope, if affected, do not drive or operate machinery.
Symptoms: Diarrhoea, abdominal cramps, fluid and electrolyte loss. Management: Minimise or prevent absorption by emesis or gastric lavage shortly after ingestion. Correction of electrolyte imbalance and fluid replacement is required. May consider admin of antispasmodics.
Drug Interactions
Increased risk of electrolyte imbalance w/ diuretics or adreno-corticosteroids. Increased sensitivity to cardiac glycosides resulting from electrolyte imbalance. Reduced laxative action w/ antibiotics.
Description: Sodium picosulfate is a locally acting laxative which has a dual action of stimulating the mucosa of both the large intestine causing colonic peristalsis and of the rectum causing increased motility and a feeling of rectal fullness.
Onset: W/in 6-12 hr.
Absorption: Absorbed small amount.
Metabolism: Metabolised by colonic bacteria to the active form, bis(p-hydroxyphenyl)pyridyl-2-methane.
Excretion: Via urine.
Chemical Structure

Chemical Structure Image
Sodium picosulfate

Source: National Center for Biotechnology Information. PubChem Database. Sodium picosulfate, CID=68654, (accessed on Jan. 23, 2020)

Store below 25°C.
MIMS Class
Laxatives, Purgatives
ATC Classification
A06AB08 - sodium picosulfate ; Belongs to the class of contact laxatives.
Buckingham R (ed). Sodium Picosulfate . Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 08/03/2016.

Joint Formulary Committee. Sodium Picosulfate . British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. Accessed 08/03/2016.

Sodium Picosulfate 5 mg/5 mL Oral Solution (Dalkeith Laboratories Limited). MHRA. Accessed 08/03/2016.

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