Sodium chloride

Generic Medicine Info
Indications and Dosage
Adult: Dosage, rate, and duration of administration are to be individualised and depends on age, weight, clinical condition,  and laboratory response to treatment.

Replacement of fluid and electrolytes
Adult: Dosage, rate, and duration of administration are to be individualised and depends on age, weight, fluid/electrolyte condition, and on the patient’s clinical and laboratory response to treatment.

Irrigation of the bladder, eye, general skin and wound cleansing
Adult: As 0.9% solution: Use as required.

Nasal congestion
Adult: As 0.9% solution: Use as required.
Child: 0.9% used as nasal drops.

Prophylaxis of muscle cramps during routine haemodialysis
Adult: As modified-release preparation: 6-10 g every dialysis session.

Chronic salt-losing conditions
Adult: As modified-release preparation: 2.4-4.8 g (40-80 mmol sodium) daily accompanied by suitable fluid intake. Up to 12 g daily may be necessary in severe cases.

Oral hygiene
Adult: As mouthwash: Rinse or gargle as required.
Renal Impairment
Chronic salt-losing conditions: Dosage adjustment may be necessary.
Conditions whereby admin of sodium chloride would be detrimental. Not to be used to induce emesis. Sustained release tablets: GI disorders associated with strictures or diverticula.
Special Precautions
Hypertension, heart failure, peripheral or pulmonary oedema, impaired renal function, liver cirrhosis, preeclampsia. Maintain adequate water intake. Pregnancy. Inj of 3 or 5% sodium chloride solution should be given via a large vein at a rate not exceeding 100 ml/hr. Monitor fluid balance, serum electrolytes and acid base balance espcially during prolonged treatment. Caution when used in patients who are receiving corticosteroids or corticotropin.
Adverse Reactions
Hypernatraemia; thirst, reduced salivation and lachrymation, fever, tachycardia, hypertension, headache, dizziness, restlessness, irritability and weakness.
Potentially Fatal: Intra-amniotic inj of hypertonic solutions: Disseminated intravascular coagulation, renal necrosis, cervical and uterine lesions, pulmonary embolism, pneumonia and death.
Inhalation/Respiratory/Irrigation/IV/Nasal/Ophth/Parenteral/PO: C
Drug Interactions
May affect serum concentrations of lithium.
Description: Sodium chloride is the major extracellular cation. It is important in electrolyte and fluid balance, osmotic pressure control and water distribution as it restores sodium ions. It is used as a source of electrolytes and water for hydration, treatment of metabolic acidosis, priming solution in haemodialysis and treatment of hyperosmolar diabetes. It is also used as diluents for infusion of compatible drug additives.
Absorption: Well-absorbed from the GI tract.
Excretion: Mainly in the urine, with small amounts excreted in the sweat, faeces, tears and saliva.
MIMS Class
Electrolytes / Intravenous & Other Sterile Solutions / Nasal Decongestants & Other Nasal Preparations / Other Eye Preparations / Preparations for Oral Ulceration & Inflammation
Disclaimer: This information is independently developed by MIMS based on Sodium chloride from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
  • NS Albert David
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