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The recommended dose of Sitagliptin is 100 mg once daily. Sitagliptin can be taken with or without food.
For patients with mild renal insufficiency (creatinine clearance [CrCl] >50 ml/min), no dosage adjustment is required.
For patients with moderate renal insufficiency (CrCl >30 to <50 ml/min women), the dose of Sitagliptin is 50 mg once daily.
For patients with severe renal insufficiency (CrCl <30 ml/min) or with end-stage renal disease (ESRD) requiring hemodialysis or peritoneal dialysis, the dose of Sitagliptin is 25 mg once daily.
Pediatric Use: Safety and effectiveness of Sitagliptin in pediatric patients under 18 years of age have not been established.
Geriatric Use: No overall differences in safety of effectiveness were observed between subjects over 65 years. The drug is excreted by the kidney. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection in the elderly.
