Sita Overdosage

Employ the usual supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring (including obtaining an electrocardiogram), and institute supportive therapy if required. Sitagliptin is modestly dialysable. It is not known whether Sitagliptin is dialysable by peritoneal dialysis or not.
Effects on blood pressure: In hypertensive patients on one or more anti-hypertensive medicines (including angiotensin-converting enzyme inhibitors, angiotensin-II antagonists, calcium-channel blockers, beta-blockers and diuretics), co-administration with Sitagliptin was generally well tolerated. In these patients, Sitagliptin had a modest blood pressure lowering effect; 100 mg per day of Sitagliptin reduced 24-hour mean ambulatory systolic blood pressure by approximately 2 mm Hg. Reductions have not been observed in subjects with normal blood pressure.
Cardiac Electrophysiology: At the recommended dose of 100 mg, there was no effect on the QTc interval obtained at the peak plasma concentration.