Sita-Met Dosage/Direction for Use

Base dosage selection of sitagliptin/metformin on the patient's current dose of these agents (max, sitagliptin 100 mg/metformin 2,000 mg daily).
Patients Inadequately Controlled on Metformin Monotherapy: Adults: Start with sitagliptin 50 mg twice daily plus the current dose of metformin. For patients taking metformin 850 mg twice daily, the recommended starting dosage is sitagliptin 50 mg/metformin 1,000 mg twice daily.
Patients Inadequately Controlled on Sitagliptin Monotherapy: Adults: Start with sitagliptin 50 mg/metformin 500 mg twice daily. Titrate patient up to 50 mg/metformin 1,000 mg twice daily. Patients taking sitagliptin monotherapy whose dose has been adjusted for renal function impairment should not be switched to sitagliptin plus metformin.
Patients Inadequately Controlled on Dual Combination Therapy With Any 2 of the Following: Antihyperglycemic Agents: Sitagliptin, Metformin, or a Sulfonylurea: Adults: The usual starting dosage should provide sitagliptin dosed as 50 mg twice daily. In determining the starting dose of metformin, the patient's level of glycemic control and current dose, if any, of metformin should be considered. Gradual dose escalation to reduce the Gastro Intestinal adverse reactions associated with metformin should be considered. Patients currently receiving or initiating a sulfonylurea may require lower sulfonylurea doses to reduce the risk of hypoglycemia.
Patients Inadequately Controlled With Diet and Exercise Alone: Adults: Start with sitagliptin 50 mg/metformin 500 mg twice daily. Patients with inadequate glycemic control on this dosage can be titrated up to sitagliptin 50 mg/metformin 1,000 mg twice daily.
Patients Switching From Sitagliptin Coadministered with Metformin: Adults: Initiate therapy with dose of sitagliptin and metformin already being taken.
General Advice: In general, administer twice daily with meals.