The recommended starting dose is 100 mg once daily, taken before the first meal of the day. Dose can be increased to 300 mg once daily in patients tolerating Canagliflozin 100 mg once daily who have an eGFR of 60 ml/min/1.73 m2 or greater and require additional glycemic control. Canagliflozin is limited to 100 mg once daily in patients who have an eGFR of 45 to less than 60 ml/min/1.73 m2. Assess renal function before initiating Canagliflozin. Do not initiate Canagliflozin if eGFR is below 45 ml/min/1.73 m2.