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Intravenous use: Reconstitute each vial with the volume of solvent shown in the following table, using one of the compatible solvents for reconstitution. Swirl until dissolved. (See table.)
Click on icon to see table/diagram/image*Compatible solvents for reconstitution: 0.9% (9 mg/ml) sodium chloride solution for injection; Sterile water for injections; Glucose 5%.
The reconstituted solutions should be withdrawn from the vial by syringe. When reconstituted as directed, the vial contents withdrawn by syringe will provide the labelled amount of piperacillin and tazobactam.
The reconstituted solutions may be further diluted to the desired volume (e.g. 50 ml to 150 ml) with one of the following compatible solvents: 0.9% (9 mg/ml) sodium-chloride solution for injection; Glucose 5%; Sterile water for injections; Dextran 6% in 0.9% sodium chloride.
Incompatibilities: Whenever piperacillin/tazobactam is used concurrently with another antibiotic (e.g. aminoglycosides), the substances must be administered separately. The mixing of beta-lactam antibiotics with an aminoglycoside in vitro can result in substantial inactivation of the aminoglycoside.
Piperacillin/tazobactam should not be mixed with other substances in a syringe or infusion bottle since compatibility has not been established.
Piperacillin/tazobactam should be administered through an infusion set separately from any other substances unless compatibility is proven.
Due to chemical instability, piperacillin/tazobactam should not be used in solutions that contain sodium bicarbonate.
Lactated Ringer's (Hartmann's) solution is not compatible with piperacillin/tazobactam.
Piperacillin/tazobactam should not be added to blood products or albumin hydrolysates.
