piperacillin + tazobactam


Laboratorio Reig Jofre


Concise Prescribing Info
Piperacillin Na 4 g, tazobactam Na 0.5 g
Bacterial infections affecting lower resp tract, urinary tract, abdomen, skin or blood in adults & adolescents. Infections of abdomen eg, appendicitis, peritonitis & gallbladder in childn 2-12 yr.
Dosage/Direction for Use
Adult & adolescent ≥12 yr 4 g/0.5 g as 30-min infusion every 6-8 hr. Childn 2-12 yr Abdominal infection 100 mg/12.5 mg/kg as 30-min infusion every 8 hr. Low WBC count 80 mg/10 mg/kg every 6 hr. Max: 4 g/0.5 g daily. Duration: 5-14 days.
Hypersensitivity to piperacillin, tazobactam, penicillins, cephalosporins or other β-lactamase inhibitors.
Special Precautions
Convulsions; new or worsening infection. Patient w/ allergies; diarrhoea before, during or after treatment; low K levels. Concomitant use w/ anticoagulants. May affect lab tests. Perform regular blood tests in patients w/ kidney or liver problems, on haemodialysis. Pregnancy & lactation. Not recommended in childn <2 yr.
Adverse Reactions
Swelling of face, lips, tongue or other parts of the body, shortness of breath, wheezing or trouble in breathing, severe rash, itching or hives on skin, yellowing of eyes or skin, damage to blood cells. Diarrhoea, vomiting, nausea; skin rashes.
Drug Interactions
Prolonged clearance w/ probenecid. Heparin, warfarin or aspirin, muscle relaxants during surgery; medicines that reduce K levels; tobramycin or gentamycin. Reduced clearance of methotrexate.
MIMS Class
ATC Classification
J01CR05 - piperacillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Salataz powd for soln for infusion
10 × 1's
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