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When administered with cyclosporine, the blood level of rosuvastatin increases 7-fold, and this could increase the side effects of rosuvastatin.
Rosuvastatin increases the action of the blood thinner warfarin and could increase the risk of bleeding from warfarin. Antacids reduce the absorption of rosuvastatin and should be administered 2 hrs after administration of rosuvastatin. The use of rosuvastatin with nicotinic acid, gemfibrozil or other drugs that may cause liver or muscle injury may increase the incidence of the muscle injury.
