10 mg & 20 mg tablet: ROSUVAPAC is contraindicated: in patients with hypersensitivity to rosuvastatin or to any of the excipients; in patients with active liver disease including unexplained, persistent elevations of serum transaminases and any serum transaminase elevation exceeding 3 x the upper limit of normal (ULN); in patients with severe renal impairment (creatinine clearance <30 mL/min); in patients with myopathy; in patients receiving concomitant ciclosporin.