Not to be taken w/ foods, drinks & medicinal products containing polyvalent cations eg, Ca, Mg, Fe & Al. Osteonecrosis of the jaw. Patients w/ history of oesophageal disorders (eg, stricture or achalasia); unable to stay in upright position for at least 30 min after taking the tab; active or recent oesophageal or upper GI problems. Treat hypocalcaemia & other bone & mineral metabolism disturbances (ie, parathyroid dysfunction, hypovitaminosis D) prior to therapy. Consider dental exam w/ appropriate preventive dentistry prior to treatment in patients w/ concomitant risk factors (eg, cancer, chemotherapy, RT, corticosteroids, poor oral hygiene) & avoid invasive dental procedures during treatment. Not to be taken by patients w/ rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Not to be used during pregnancy or lactation. Childn & adolescents. Elderly >80 yr.