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Symptoms: In case of overdosage, one or more of the following may occur: Severe nausea, vomiting, muscle weakness, abdominal cramps, leakage of urine and faeces, increased saliva, watering eyes, sweating, rapid heart rate, serious heart rhythm disorder, slow heartbeat, low blood pressure, breathing difficulties, fainting, seizures or collapse.
Treatment: As in any case of overdosage, general supportive measures should be used.
In severe cases, anticholinergics eg, atropine may be used as a general antidote for cholinomimetics. An initial dose of 0.5-1 mg IV is recommended, with subsequent doses based on the clinical response.
Because strategies for the management of overdosage are continually evolving, it is advisable to contact a poison control centre to determine the latest recommendations for the management of an overdosage.
