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Rabeprazole like other PPIs is metabolized through cytochrome P-450 drug metabolizing enzyme system. But rabeprazole does not have clinically significant interaction with other drugs metabolized by CYP450 system eg, warfarin, theophylline, diazepam and phenytoin.
Rabeprazole inhibits gastric acid secretion and may interfere with absorption of drugs where gastric pH is an important determinant of bioavailability eg, ketoconazole, iron salts and digoxin.
In studies, no interaction with liquid antacid or foods was observed.
