Contraindications
Thromboembolic diseases, undiagnosed abnormal vaginal bleeding. Patients with oestrogen-dependent tumours.
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Special Precautions
Prolonged exposure to unopposed oestrogen may increase the risk of endometrial cancer. Porphyria.
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Adverse Reactions
May cause contact sensitisation upon prolonged usage.
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Lab Interference
May interfere with thyroid function and glucose tolerance tests.
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Action
Description: Promestriene is an estradiol derivative that has been used topically in menopausal atrophic vaginitis and in seborrhoea.
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