The most likely adverse event in case of overdose is hypotension, with clinical possibility of nausea, vomiting, hypotension in Preterax 5 mg, cramps, dizziness, sleepiness, mental confusion, polyuria or oliguria which may progress to anuria (due to hypovolaemia). Salt and water disturbances (low sodium levels, low potassium levels) may occur.
The first measures to be taken consist of rapid elimination of the products ingested by gastric lavage and/or administration of activated charcoal, then restoration of fluid and electrolyte balance in a specialised centre until they return to normal.
If marked hypotension occurs, this can be treated by placing the patient in a supine position with the head lowered. If necessary, an IV infusion of isotonic saline may be given, or any other method of volaemic expansion may be used.
Perindoprilate, the active form of perindopril, can be dialysed (see Pharmacology: Pharmacokinetics under Actions).