Preterax Contraindications

Linked to Perindopril: Preterax should never be used in cases of hypersensitivity to perindopril or to any other angiotensin-converting enzyme inhibitors; previous history of angioneurotic oedema (Quincke's oedema) linked to treatment with an angiotensin-converting enzyme inhibitor; hyperkalemia; pregnancy; lactation.
Preterax 2.5 mg: Hereditary or idiopathic angioneurotic oedema.
Preterax 2.5 mg/5 mg is generally not recommended in combinations with potassium-sparing diuretics, potassium salts, lithium (see Interactions); bilateral renal artery stenosis or single functioning kidney; increased potassium levels.
Concomitant use of PRETERAX with aliskiren-containing products in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m²). Concomitant use with sacubitril/valsartan (see WARNINGS* and INTERACTIONS*), extracorporeal treatments leading to contact of blood with negatively charged surfaces (see INTERACTIONS*), significant bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney (see WARNINGS*).
Linked to Indapamide: Preterax should never be used in cases of hypersensitivity to sulphonamides; severe renal failure (creatinine clearance <30 mL/min), hepatic encephalopathy, severe impairment of liver function; hypokalaemia.
As a general rule, use of Preterax is not recommended in combination with non-antiarrhythmic drugs producing Torsade de pointes (see Interactions).
Linked to Preterax 2.5 mg: Hypersensitivity to any of the excipients.
As there is a lack of available data, Preterax 2.5 mg must not be used in dialysis patients; patients with untreated decompensated cardiac insufficiency.