Induction of General Anaesthesia: Adults: It is recommended that Pofol be titrated [approximately 40 mg (4 mL) every 10 sec in an average healthy adult] against the response of the patient until the clinical signs show the onset of anaesthesia.
Most adult patients <55 years are likely to require Pofol 1.5-2.5 mg/kg; reduce rates of administration (20-50 mg/min) to decrease total amount administered. The total dose required can be reduced by lower rates of administration [20-50 mg/min (2-5 mL/min)].
Over 55 years, the requirement will generally be less. In patients of American Society of Anaesthesiologists (ASA) grades 3 and 4, lower rates of administration should be used [approximately 20 mg (2 mL) every 10 sec].
Children >3 Years: It is recommended that Pofol be given slowly until the clinical signs show the onset of anaesthesia. The dose should be adjusted for age and/or weight. Most patients >8 years are likely to require approximately 2.5 mg/kg of Pofol for induction of anaesthesia. Under this age, the requirements may be >2.5 mg/kg. Lower dosage is recommended for children of ASA grades 3 and 4.
Maintenance of General Anaesthesia: Adults: Anaesthesia can be maintained by administering Pofol either by continuous infusion or repeat IV injection to prevent the clinical signs of light anaesthesia.
Continuous Infusion: The required rate of administration varies considerably between patients, but rates in the region of 4-12 mg/kg/hr usually maintain satisfactory anaesthesia.
Repeat Bolus Injection: If a technique involving repeat bolus injection is used, increments of 25-50 mg may be given according to clinical need.
Children >3 Years: The required rate of administration varies considerably between patients, but rates in the region of 9-15 mg/kg/hr usually maintain satisfactory anaesthesia.
Sedation During Intensive Care: Adults: When used to provide sedation for ventilated patients undergoing intensive care, it is recommended that Pofol be titrated for a period of up to 3 days, given by continuous infusion. The infusion rate should be adjusted according to the depth of sedation required but rates in the region of 0.3-4 mg/kg/hr should achieve satisfactory sedation. Rates of infusion >4 mg/kg/hr are not recommended. Pofol may be diluted with dextrose 5% IV infusion (see Cautions for Usage).