Pofol contains no antimicrobial preservatives, the vehicle is prevented from growth of microorganisms.
When Pofol is to be aspirated, it must be drawn aseptically into a sterile syringe or giving set immediately after opening the ampoule or breaking the vial seal. Administration must commence without delay. Asepsis must be maintained for both Pofol and infusion equipment throughout the infusion period.
Any drug or fluid added to the Pofol line must be administered close to the cannula site.
Pofol must not be administered via a microbiological filter.
Pofol and any syringe containing Pofol is for single use in an individual patient.
According to the guide established in connection with the other fat emulsions, infusion period of this medication should not exceed 12 hrs. After operation or 12 hrs passage, any unused portion of Pofol and the giving set must be discarded. Any portion of the contents remaining after use must also be discarded.
Pofol has no analgesic properties and therefore, supplementary analgesic agents are required in addition to Pofol. Pofol has been used in association with spinal and epidural anaesthesia and with commonly used premedicants, neuromuscular-blocking drugs, inhalation agents and analgesic agents.
Pofol can be used for injection undiluted or diluted with 5% dextrose only. For mix-dilution, dextrose 5% IV infusion and lignocaine (lidocaine) injection fluids should be used.
When Pofol is administered diluted with dextrose 5% IV infusion in PVC bags or glass infusion bottles, dilutions which must not exceed ⅕ (propofol 2 mg/1 mL solution) should be prepared aseptically immediately before administration and must be used within 6 hrs of preparation. Usually, it is recommended that Pofol is mixed into the needed amount of dextrose 5% IV infusion. The dilution may be used with a variety of infusion control technique, but a giving set used alone will not avoid the risk of accidents eg, uncontrolled infusion of large volumes of diluted Pofol; thus, a burette, drop counter or volumetric pump must be included in the infusion line. The risk of uncontrolled infusion must be taken into account when deciding the maximum amount of Pofol in the burette. When Pofol is used undiluted to maintain anaesthesia, it is recommended that equipment eg, syringe pumps or volumetric infusion pump should always be used to control infusion rates.
Pofol may be administered via a Y-piece close with dextrose 5% IV infusion, sodium chloride 0.9% IV infusion, dextrose 4% with sodium chloride 0.18% IV infusion.
The local pain which may occur during the induction phase of Pofol anaesthesia can be minimized by the co-administration of lignocaine and by the use of the larger veins of the forearm and antecubital fossa.
Container should be shaken well before use.
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