Information on acute overdose in humans is limited. The signs and symptoms can be anticipated to be severe headache, diarrhea, hypotension, tachycardia and possibly cardiac arrhythmias. Patients should be observed and given supportive treatment. Since cilostazol is highly protein-bound, it is unlikely that it can be efficiently removed by hemodialysis or peritoneal dialysis. The stomach should be emptied by induced vomiting or gastric lavage, as appropriate. The oral LOSO of cilostazol is >5.0 g/kg in mice and rats and >2.0 g/kg in dogs.