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Indications and Dosage
Oral
Peptic ulcer Adult: 50 mg bid-tid for 4-6 wk.
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Administration
Should be taken on an empty stomach. Take 30 min before meals.
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Special Precautions
Impaired renal function, esp end-stage renal failure.
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Adverse Reactions
Dry mouth, blurred vision.
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Drug Interactions
Enhanced effect when used other drugs with antimuscarinic properties and MAOIs. May affect absorption of other drugs. Antagonistic effect with parasympathomimetics.
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Food Interaction
Decreased bioavailability when taken with food.
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Action
Description: Pirenzepine is a selective M1 tertiary amine antimuscarinic. It decreases gastric acid secretion through preferential action on gastric mucosa; also reduces pepsin secretion.
Pharmacokinetics: Absorption: Bioavailability: 20-30%. Reduced when taken with food. Distribution: 12% bound to plasma proteins. Poor diffusion across blood brain barrier. Excretion: About 10% excreted unchanged in urine, the rest in faeces. Elimination half life: 12 hr. |
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MIMS Class
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